Introduction
The 2000s were a golden era for cartoons, shaping childhoods and creating pop culture icons that still inspire fan art, memes, and reboots today. From action-packed adventures to clever comedies, these shows defined a generation. What makes them even more exciting is the hidden trivia and behind-the-scenes details only true fans know. In this list, I’ll share my picks for the 10 most influential cartoons of the 2000s, mixing personal favorites with classics that shaped animation forever.
10. Danny Phantom
Danny Phantom may not have the same mainstream fame as SpongeBob or Avatar, but it left a deep mark on 2000s animation. Created by Butch Hartman (also behind The Fairly OddParents), the show followed teenager Danny Fenton, who accidentally gains ghost powers after a lab accident. Fans loved the clever balance between superhero action, teen drama, and humor. What only true fans might remember is how the show gradually grew darker, with story arcs about betrayal, time travel, and even the hauntingly powerful villain Dan Phantom—Danny’s evil future self. The series ended in 2007 after three seasons, but it’s still considered one of Nickelodeon’s cult classics, with fans pushing for a revival even today. Its catchy theme song and unique ghost designs remain unforgettable, making Danny Phantom one of the most influential yet underrated cartoons of its era.
9. Teen Titans
Teen Titans is one of Cartoon Network’s most iconic 2000s shows, perfectly combining high-energy action, sharp humor, and surprisingly dark themes. The team—Robin, Starfire, Beast Boy, Cyborg, and Raven—is genuinely irreplaceable, each getting season-long arcs (Raven/Trigon, Cyborg/Brother Blood, Beast Boy/Brotherhood of Evil) that fans still debate. As I see it, the series ended tragically before the writers could give us everything they had under their sleeves, and I personally treat the movie where the Titans fight Trigon as the true ending. True-fan trivia: Slade was never called “Deathstroke” on air due to standards, Puffy AmiYumi’s theme alternated languages as a tone cue, and Raven’s “Azarath Metrion Zinthos” became an instant mantra. The later reboot/spinoff Teen Titans Go! is also good in its own right, but it deliberately drops the darker, serialized storytelling for fast, meta comedy—proof of how influential the original remains.
8. Totally Spies!
Totally Spies! was a groundbreaking blend of spy adventure, comedy, and teen drama that captured the early 2000s zeitgeist. Following Sam, Clover, and Alex, three high school girls who balance ordinary teenage life with secret missions for the World Organization of Human Protection (WOOHP), the show became famous for its mix of fashion, gadgets, and over-the-top villains. Fans know that many episodes contain hidden references to classic spy films and comics, and that the series occasionally tackled surprisingly dark storylines—such as mind control, betrayal, and corporate conspiracies—that are easy to miss on first viewing. The animation style, inspired by both American cartoons and Japanese anime, gave the series a unique flair and inspired other spy-themed teen shows. Long-time fans also recall that the series’ popularity in Europe often outpaced the U.S., leading to numerous merchandise lines and even a few made-for-TV movies. While some critics dismissed it as just a “girly cartoon,” the show’s clever writing, iconic characters, and mix of humor and suspense make it one of the most influential cartoons of the decade.
7. Ed, Edd n Eddy
Ed, Edd n Eddy is one of Cartoon Network’s longest-running and most influential series of the 2000s, and it’s beloved for good reason. The show follows three friends—Ed, Edd (Double D), and Eddy—as they endlessly scheme to scam their neighborhood peers out of jawbreakers. True fans know that behind the slapstick humor lies an incredible attention to detail: each character has unique quirks, and the suburban cul-de-sac setting is meticulously designed with visual gags hidden in the background. The series also experimented with timing and animation style, giving it a signature wobbly, exaggerated look that still stands out today. While many episodes are comedic in nature, some tackled surprisingly dark or relatable themes, like social hierarchy, loneliness, and the desire for friendship. Fun trivia: the show’s creator, Danny Antonucci, insisted on hand-drawn animation at a time when most cartoons were moving to digital, giving the series its distinctive charm. Long-time fans also remember the 2009 TV movie Ed, Edd n Eddy’s Big Picture Show, which served as a satisfying conclusion to many story arcs and is often considered essential viewing.
6. Samurai Jack
Samurai Jack is a visually stunning and highly influential series that redefined action cartoons in the 2000s. Created by Genndy Tartakovsky, the show follows the lone samurai Jack as he battles the evil shape-shifting demon Aku across a dystopian future. Fans know that its unique storytelling relies heavily on visuals, minimal dialogue, and cinematic framing, giving it a style that feels more like an animated film than a traditional cartoon. The series is famous for experimenting with pacing—some episodes are nearly silent, building tension with music and imagery alone—while others deliver fast-paced, intricate fight sequences. True fans also appreciate the subtle continuity: Jack’s journey through time, recurring motifs, and hints of past and future events enrich every viewing. The original run ended in 2004, but the 2017 revival wrapped up Jack’s story in a darker, more mature tone, staying true to the series’ legacy while providing closure for long-time fans. Its influence can be seen in countless action and adventure cartoons that followed, cementing Samurai Jack as a milestone of early 2000s animation.
5. Phineas and Ferb
Phineas and Ferb is one of the most inventive and enduring cartoons of the 2000s, known for its clever humor, catchy songs, and boundless creativity. The show follows stepbrothers Phineas and Ferb as they embark on outrageous, day-long projects, while their sister Candace constantly tries—and fails—to “bust” them. True fans will notice the intricate running gags, hidden Easter eggs, and clever wordplay scattered throughout episodes, rewarding repeat viewings. The show’s musical numbers, often written by series creators Dan Povenmire and Jeff “Swampy” Marsh, became iconic, earning Emmy nominations and even inspiring live performances. Another fun detail: Perry the Platypus’s silent spy persona was inspired by classic spy films, and his battles with Dr. Doofenshmirtz subtly parody cinematic tropes while remaining hilarious for kids. Despite its lighthearted premise, the series occasionally delves into surprisingly clever science fiction ideas, time travel, and moral lessons without ever feeling preachy. With its mix of humor, heart, and ingenuity, Phineas and Ferb remains one of the most influential and beloved cartoons of its era.
4. The Fairly OddParents
The Fairly OddParents is a quintessential early-2000s cartoon that mixes slapstick comedy, clever writing, and a surprisingly layered world of magic. The show follows Timmy Turner, a ten-year-old boy with fairy godparents Cosmo and Wanda, who grant his every wish—often leading to chaos and hilarity. True fans know that beyond the surface-level humor, many episodes contain sly cultural references, parodies of movies and TV shows, and moral lessons wrapped in outrageous scenarios. One fun fact: Timmy’s teacher, Mr. Crocker, was inspired by classic villain archetypes, and his obsession with fairies became a running gag that evolved with the series. The show also frequently experimented with different animation styles, dream sequences, and meta-commentary, keeping long-time viewers engaged. While critics sometimes pointed out that the formula could feel repetitive, the series’ sharp writing, memorable characters, and enduring humor have cemented it as one of Nickelodeon’s most influential cartoons. Fans also appreciate the clever cameos and subtle jokes that only repeat viewers catch, making it a show with layers beyond the obvious gags.
3. Ben 10
Ben 10 is the ultimate summer vacation show for kids, packed with action, adventure, and creativity. The series follows Ben Tennyson, a boy who discovers the Omnitrix, a device that allows him to transform into multiple alien heroes, each with unique powers. True fans know the show shines not just for its inventive aliens and gadgets, but also for its well-developed side characters. Gwen, Ben’s cousin, is a smart and resourceful ally whose mastery of magic and technology often saves the day, while Grandpa Max provides wisdom, tactical guidance, and experience as a seasoned Plumber, giving depth and heart to the family dynamic.
The villains are equally memorable: Vilgax, a powerful alien warlord, poses a constant threat, while Dr. Animo, a mad scientist obsessed with creating mutant creatures, and Kevin 11, a former friend turned rival with the ability to absorb powers, add layers of suspense and excitement. Many of these villains return in later episodes, creating long-term story arcs that reward loyal viewers. The original series perfectly captures a sense of American adventure, from roadside towns to secret alien invasions, and balances humor with genuinely thrilling action. While the later continuations were enjoyable, none matched the charm, suspense, and popularity of the original run. Every time a past villain resurfaces, you know the episode will deliver high-stakes fun, making Ben 10 a standout and influential series of the 2000s.
2. SpongeBob SquarePants
SpongeBob SquarePants is arguably one of the most influential cartoons of the 2000s, blending absurd humor, clever writing, and unforgettable characters. The show follows SpongeBob, an eternally optimistic sea sponge who works at the Krusty Krab in Bikini Bottom. True fans know that the series’ brilliance lies in its layered comedy—children enjoy the slapstick and silly antics, while adults can appreciate subtle satire, clever wordplay, and social commentary hidden within episodes.
Key side characters, like Patrick Star, SpongeBob’s dim-witted yet loyal best friend, and Squidward Tentacles, the perpetually annoyed neighbor, elevate the show with their unique personalities and dynamic interactions. Even supporting roles like Mr. Krabs, Plankton, and Sandy Cheeks have depth that makes their recurring schemes and antics endlessly entertaining. The series has also been lauded for its creativity, from absurd inventions to imaginative underwater worlds. While some critics argue that later seasons lost some of the charm of the original run, its influence is undeniable: SpongeBob SquarePants shaped the tone and style of countless animated series, earned a massive fanbase, and cemented itself as a cultural icon that continues to inspire memes, merchandise, and even Broadway adaptations.
1. Avatar: The Last Airbender
Avatar: The Last Airbender is not accidentally considered one of the greatest animated series of all time. Its world-building, character development, storytelling, writing, and music are all top-tier, creating a rich and immersive universe that still stands out today. Every character has a clear purpose in the story, and the dynamics between them—especially within Team Avatar—are some of the best seen in any fictional work. The relationships between Aang, Katara, Sokka, Toph, and later Zuko are multi-layered, evolving naturally over time with emotional depth and humor.
The world itself, inspired by various Asian cultures, is remarkably realistic, from the bending styles and martial arts influences to architecture and spiritual elements. Villains like Fire Lord Ozai, Azula, and later antagonists are compelling, well-developed, and memorable, adding tension and stakes that keep viewers engaged. True fans know that the show balances serious drama with lighthearted moments flawlessly, and while there are a few weaker episodes in the first season, the overall quality never wavers. The music, crafted to enhance every scene, the subtle foreshadowing, and the overarching narrative about balance, growth, and responsibility make Avatar: The Last Airbender not just influential for the 2000s, but timeless in its appeal.
